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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Ubiquitin-conjugating enzyme E2 D2

UniprotKB/SwissProt ID: UB2D2_MOUSE (P62838)

Gene Name: Ube2d2

Synonyms: Ubc4, Ubch4, Ubch5b, Ube2d2a

Organism: Mus musculus (Mouse).

Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP- induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3 (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

Network with metabolic pathway:
Kegg map ID Pathway Link
map04120Ubiquitin mediated proteolysis
map04141Protein processing in endoplasmic reticulum
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000608

The S-nitrosylation sites of UB2D2_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
185HPNINSNGSI C LDILRSQWSP CCCCCCCCCE E EEECCCCCCC 2.75%MC0420925432in vivo
2111KVLLSICSLL C DPNPDDPLVP HHHHHHHHHH C CCCCCCCCHH 11.23%MC1320925432in vivo