Protein Name: Ubiquitin-like modifier-activating enzyme 6
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UniprotKB/SwissProt ID: UBA6_HUMAN (A0AVT1)
Gene Name: UBA6
Synonyms: MOP4, UBE1L2
Organism: Homo sapiens (Human).
Function: Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin- E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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Network with metabolic pathway:
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Graphical Visualization of S-nitrosylation Sites:
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| Overview of Protein S-nitrosylation Sites with Functional and Structural Information |  |
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