UniprotKB/SwissProt ID: UBC12_HUMAN (P61081)
Gene Name: UBE2M
Synonyms: UBC12
Organism: Homo sapiens (Human).
Function: Accepts the ubiquitin-like protein NEDD8 from the UBA3- NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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PDB :
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