Protein Name: Ubiquitin carboxyl-terminal hydrolase isozyme L1
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UniprotKB/SwissProt ID: UCHL1_HUMAN (P09936)
Gene Name: UCHL1
Organism: Homo sapiens (Human).
Function: Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Endoplasmic reticulum membrane; Lipid-anchor. Note=About 30% of total UCHL1 is associated with membranes in brain.
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Protein disease:
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Disease database |
Database Entry |
Disease information | KEGG | H00057 | Parkinson's disease (PD) | OMIM | 191342 | UBIQUITIN CARBOXYL-TERMINAL ESTERASE L1; UCHL1 ;;UBIQUITIN C-TERMINAL HYDROLASE, NEURON-SPEC | OMIM | 613643 | PARKINSON DISEASE 5, AUTOSOMAL DOMINANT; PARK5 | HPRD | 01877 | Parkinson disease | HPRD | 01877 | Parkinson disease, resistance to |
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Network with metabolic pathway:
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Graphical Visualization of S-nitrosylation Sites:
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Overview of Protein S-nitrosylation Sites with Functional and Structural Information | |
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