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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Ubiquitin carboxyl-terminal hydrolase isozyme L1

UniprotKB/SwissProt ID: UCHL1_HUMAN (P09936)

Gene Name: UCHL1

Organism: Homo sapiens (Human).

Function: Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Endoplasmic reticulum membrane; Lipid-anchor. Note=About 30% of total UCHL1 is associated with membranes in brain.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Protein disease:
Disease database Database Entry Disease information
KEGGH00057 Parkinson's disease (PD)
OMIM191342UBIQUITIN CARBOXYL-TERMINAL ESTERASE L1; UCHL1 ;;UBIQUITIN C-TERMINAL HYDROLASE, NEURON-SPEC
OMIM613643PARKINSON DISEASE 5, AUTOSOMAL DOMINANT; PARK5
HPRD01877Parkinson disease
HPRD01877Parkinson disease, resistance to
Network with metabolic pathway:
Kegg map ID Pathway Link
map05012Parkinson's disease
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001578

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
2ETL X-ray 2.40 A A/B1-223Link
2LEN NMR - A1-223Link
3IFW X-ray 2.40 A A1-223Link
3IRT X-ray 2.80 A A/B1-223Link
3KVF X-ray 2.80 A A1-223Link
3KW5 X-ray 2.83 A A1-223Link
4DM9 X-ray 2.35 A A/B1-223Link

The S-nitrosylation sites of UCHL1_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1152AHDAVAQEGQ C RVDDKVNFHF HHHHHHCCCC C EEEHEEEEEE 7.23%HC0819483679in vivo
2220GEVRFSAVAL C KAA------- CCEEEEEEEE E ECC 1.71%HC012212679in vitro
3220GEVRFSAVAL C KAA------- CCEEEEEEEE E ECC 1.71%HC0119483679in vivo