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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: V-type proton ATPase subunit H

UniprotKB/SwissProt ID: VATH_MOUSE (Q8BVE3)

Gene Name: Atp6v1h

Organism: Mus musculus (Mouse).

Function: Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

Network with metabolic pathway:
Kegg map ID Pathway Link
map00190Oxidative phosphorylation
map04721Synaptic vesicle cycle
map05323Rheumatoid arthritis
map04142Lysosome
map04145Phagosome
map05152Tuberculosis
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR004908
IPR011987
IPR011989

The S-nitrosylation sites of VATH_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
173QEMLQTEGSQ C AKTFINLMTH HHHHHCCCHH H HHHHHHHHHH 4.49%MC0621278135in vitro