Protein Name: Voltage-dependent anion-selective channel protein 1
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UniprotKB/SwissProt ID: VDAC1_HUMAN (P21796)
Gene Name: VDAC1
Synonyms: VDAC
Organism: Homo sapiens (Human).
Function: Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion outer membrane. Cell membrane.
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PDB :
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Protein disease:
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| Disease database |
Database Entry |
Disease information | | OMIM | 604492 | VOLTAGE-DEPENDENT ANION CHANNEL 1; VDAC1 ;;PORIN;; OMP2, YEAST, HUMAN COMPLEMENT OF VDAC DEF |
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Network with metabolic pathway:
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Graphical Visualization of S-nitrosylation Sites:
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| Overview of Protein S-nitrosylation Sites with Functional and Structural Information |  |
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