logo
  Home | Contact us | Browse | Quick Search by UniProtKB ID, Keyword, PDBID

Menu:

Latest news:

Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

Read more...


Protein Name: Voltage-dependent anion-selective channel protein 2

UniprotKB/SwissProt ID: VDAC2_MOUSE (Q60930)

Gene Name: Vdac2

Synonyms: Vdac6

Organism: Mus musculus (Mouse).

Function: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation- selective (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion outer membrane.

Network with metabolic pathway:
Kegg map ID Pathway Link
map04020Calcium signaling pathway
map05012Parkinson's disease
map05016Huntington's disease
map05166HTLV-I infection
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001925

The S-nitrosylation sites of VDAC2_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
148LVKLDVKTKS C SGVEFSTSGS CEEEEEEEEC C CCCEEEEEEC 4.35%MC0924895380-
248LVKLDVKTKS C SGVEFSTSGS CEEEEEEEEC C CCCEEEEEEC 4.35%MC0921278135in vitro
348LVKLDVKTKS C SGVEFSTSGS CEEEEEEEEC C CCCEEEEEEC 4.35%MC0922865876in vivo
477SGTLETKYKW C EYGLTFTEKW EEEEEEEEEE C CCCEEEEEEE 2.23%MC0322588120-
577SGTLETKYKW C EYGLTFTEKW EEEEEEEEEE C CCCEEEEEEE 2.23%MC0324895380-
677SGTLETKYKW C EYGLTFTEKW EEEEEEEEEE C CCCEEEEEEE 2.23%MC0321278135in vitro
777SGTLETKYKW C EYGLTFTEKW EEEEEEEEEE C CCCEEEEEEE 2.23%MC0322865876in vivo
8104GTEIAIEDQI C QGLKLTFDTT EEEEEEECCC C CCEEEEEEEE 1.87%MC0724895380-
9104GTEIAIEDQI C QGLKLTFDTT EEEEEEECCC C CCEEEEEEEE 1.87%MC0721278135in vitro
10104GTEIAIEDQI C QGLKLTFDTT EEEEEEECCC C CCEEEEEEEE 1.87%MC0722865876in vivo
11211EFGGSIYQKV C EDFDTSVNLA EEEEEEEEEE C CCCCEEEEEE 5.53%MC0922865876in vivo
12228VNLAWTSGTN C TRFGIAAKYQ EEEEEEEECC C CCEEEEEEEE 2.65%MC0622865876in vivo