Protein Name: Vinculin
|
UniprotKB/SwissProt ID: VINC_HUMAN (P18206)
Gene Name: VCL
Organism: Homo sapiens (Human).
Function: Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell- surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, focal adhesion. Note=Cytoplasmic face of adhesion plaques. Recruitment to cell-cell junctions occurs in a myosin II-de
|
PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. ) |
|
Protein disease:
|
| Disease database |
Database Entry |
Disease information | | KEGG | H00292 | Hypertrophic cardiomyopathy (HCM) | | KEGG | H00294 | Dilated cardiomyopathy (DCM) | | OMIM | 193065 | VINCULIN; VCL METAVINCULIN, INCLUDED | | OMIM | 611407 | CARDIOMYOPATHY, DILATED, 1W; CMD1W | | OMIM | 613255 | CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 15; CMH15 |
|
Network with metabolic pathway:
|
|
Graphical Visualization of S-nitrosylation Sites:
|
| Overview of Protein S-nitrosylation Sites with Functional and Structural Information |  |
|
