Protein Name: Vacuolar protein sorting-associated protein VTA1 homolog
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UniprotKB/SwissProt ID: VTA1_HUMAN (Q9NP79)
Gene Name: VTA1
Synonyms: C6orf55
Organism: Homo sapiens (Human).
Function: Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR (By similarity). Involved in HIV-1 budding.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Endosome membrane; Peripheral membrane protein (Probable).
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Protein disease:
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| Disease database |
Database Entry |
Disease information | | OMIM | 610902 | CHROMOSOME 6 OPEN READING FRAME 55; C6ORF55 ;;SKD1-BINDING PROTEIN 1; SBP1;; LYST-INTERACTIN |
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Network with metabolic pathway:
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Graphical Visualization of S-nitrosylation Sites:
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| Overview of Protein S-nitrosylation Sites with Functional and Structural Information |  |
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