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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Xanthine dehydrogenase/oxidase

UniprotKB/SwissProt ID: XDH_MOUSE (Q00519)

Gene Name: Xdh

Organism: Mus musculus (Mouse).

Function: Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm (By similarity). Peroxisome (By similarity). Secreted (By similarity).

Network with metabolic pathway:
Kegg map ID Pathway Link
map00230Purine metabolism
map00232Caffeine metabolism
map00983Drug metabolism - other enzymes
map04146Peroxisome
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000572
IPR000674
IPR001041
IPR002346
IPR002888
IPR005107
IPR006058
IPR008274
IPR012675
IPR014307
IPR014309

The S-nitrosylation sites of XDH_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1828AAYKTGRPVR C MLDRDEDMLI HHHHCCCCEE E EECCCHHHHC 3.02%MC0122178444-
2828AAYKTGRPVR C MLDRDEDMLI HHHHCCCCEE E EECCCHHHHC 3.02%MC0120837516in vivo