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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Zyxin

UniprotKB/SwissProt ID: ZYX_MOUSE (Q62523)

Gene Name: Zyx

Organism: Mus musculus (Mouse).

Function: Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm (By similarity). Cytoplasm, cytoskeleton (By similarity). Cell junction, focal adhesion (By similarity). Nucleus (By similarity). Note=Associates with the actin cytoskeleton near the adhesion plaques. Enters the nucleus in the presence of HESX1

Network with metabolic pathway:
Kegg map ID Pathway Link
map04510Focal adhesion
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001781

The S-nitrosylation sites of ZYX_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1376QRQSVAVNES C GKCNQPLARA CCCCCCCCCC C CCCCCCCCCC 5.01%MC0321278135in vitro