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UbiNet is a web-based system that provides a comprehensive collection of available ubiquitinated substrate proteins, ligating enzyme E3, E3-substrate specificities and a systematic framework for the analysis of E3 ligase regulatory networks in protein ubiquitination, focusing on Human organism. Currently, UbiNet contains 2 E1s, 46E2s, 499 E3s and 14692 ubiquitinated substrate proteins in Human, and 10437 E3-substrate specific relations between 438 E3 ligases and 2839 ubiquitinated substrate proteins. In addition, 418891 records of protein-protein interaction (PPI), 286758 records of DDI (domain-domain interaction), and 2143 records of E3-associated functional categories (including pathway, cellular process, molecular function, cellular localization, protein complex, protein family, and disease) were collected serving for the analysis.

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Rank Data type Number of data Downloadable
1
Ubiquitinated substrate proteins
14692
2
E3 ligases
499
3
E1 activating + E2 conjugating
2+46
4
Protein - Protein interaction
430530
5
Domain - Domain interaction
286758
6
E3-associated functional categories
2143