UbiNet

No.	E3_ID	Category	Term_ID	Term_Name	No. of proteins recognized by E3 via PPI
1	CBL_HUMAN	KEGG	4144	Endocytosis	111
2	CBL_HUMAN	KEGG	4510	Focal adhesion	111
3	CBL_HUMAN	KEGG	4810	Regulation of actin cytoskeleton	111
4	CBL_HUMAN	KEGG	5200	Pathways in cancer	111
5	CBL_HUMAN	KEGG	5215	Prostate cancer	111
6	CBL_HUMAN	KEGG	4012	ErbB signaling pathway	111
7	CBL_HUMAN	KEGG	4060	Cytokine-cytokine receptor interaction	111
8	CBL_HUMAN	KEGG	4664	Fc epsilon RI signaling pathway	111
9	PRC1_HUMAN	KEGG	5322	Systemic lupus erythematosus	7
10	MIB2_HUMAN	KEGG	4330	Notch signaling pathway	6
11	MIB1_HUMAN	KEGG	4330	Notch signaling pathway	8
12	MDM2_HUMAN	KEGG	5215	Prostate cancer	133
13	CBLB_HUMAN	KEGG	4012	ErbB signaling pathway	15
14	TTC3_HUMAN	KEGG	4150	mTOR signaling pathway	7
15	TTC3_HUMAN	KEGG	5213	Endometrial cancer	7
16	TTC3_HUMAN	KEGG	5221	Acute myeloid leukemia	7
17	ITCH_HUMAN	KEGG	4012	ErbB signaling pathway	47
18	TTC3_HUMAN	KEGG	5223	Non-small cell lung cancer	7
19	TTC3_HUMAN	KEGG	4920	Adipocytokine signaling pathway	7
20	TTC3_HUMAN	KEGG	5210	Colorectal cancer	7
21	MDM2_HUMAN	KEGG	5218	Melanoma	133
22	TTC3_HUMAN	KEGG	5214	Glioma	7
23	TTC3_HUMAN	KEGG	5218	Melanoma	7
24	TTC3_HUMAN	KEGG	4370	VEGF signaling pathway	7
25	TTC3_HUMAN	KEGG	5211	Renal cell carcinoma	7
26	TTC3_HUMAN	KEGG	4664	Fc epsilon RI signaling pathway	7
27	TTC3_HUMAN	KEGG	5212	Pancreatic cancer	7
28	TTC3_HUMAN	KEGG	5220	Chronic myeloid leukemia	7
29	TTC3_HUMAN	KEGG	4662	B cell receptor signaling pathway	7
30	TTC3_HUMAN	KEGG	4914	Progesterone-mediated oocyte maturation	7
31	TTC3_HUMAN	KEGG	5222	Small cell lung cancer	7
32	TTC3_HUMAN	KEGG	4210	Apoptosis	7
33	TTC3_HUMAN	KEGG	5215	Prostate cancer	7
34	TTC3_HUMAN	KEGG	4666	Fc gamma R-mediated phagocytosis	7
35	TTC3_HUMAN	KEGG	4012	ErbB signaling pathway	7
36	TTC3_HUMAN	KEGG	4620	Toll-like receptor signaling pathway	7
37	MDM2_HUMAN	KEGG	5219	Bladder cancer	133
38	TTC3_HUMAN	KEGG	4660	T cell receptor signaling pathway	7
39	M3K1_HUMAN	KEGG	5210	Colorectal cancer	133
40	TTC3_HUMAN	KEGG	4530	Tight junction	7
41	TTC3_HUMAN	KEGG	4722	Neurotrophin signaling pathway	7
42	TTC3_HUMAN	KEGG	4910	Insulin signaling pathway	7
43	M3K1_HUMAN	KEGG	5211	Renal cell carcinoma	133
44	M3K1_HUMAN	KEGG	4662	B cell receptor signaling pathway	133
45	MDM2_HUMAN	KEGG	4110	Cell cycle	133
46	TTC3_HUMAN	KEGG	4630	Jak-STAT signaling pathway	7
47	MARH8_HUMAN	KEGG	5330	Allograft rejection	1
48	MARH8_HUMAN	KEGG	4940	Type I diabetes mellitus	1
49	MARH8_HUMAN	KEGG	5332	Graft-versus-host disease	1
50	MARH8_HUMAN	KEGG	4672	Intestinal immune network for IgA production	1
51	MARH8_HUMAN	KEGG	5320	Autoimmune thyroid disease	1
52	MARH1_HUMAN	KEGG	5330	Allograft rejection	0
53	MARH8_HUMAN	KEGG	5416	Viral myocarditis	1
54	MARH8_HUMAN	KEGG	5310	Asthma	1
55	MARH1_HUMAN	KEGG	4940	Type I diabetes mellitus	0
56	MARH1_HUMAN	KEGG	5332	Graft-versus-host disease	0
57	MARH1_HUMAN	KEGG	4672	Intestinal immune network for IgA production	0
58	MARH8_HUMAN	KEGG	5322	Systemic lupus erythematosus	1
59	MARH1_HUMAN	KEGG	5320	Autoimmune thyroid disease	0
60	MARH1_HUMAN	KEGG	5310	Asthma	0
61	MARH1_HUMAN	KEGG	5416	Viral myocarditis	0
62	MARH8_HUMAN	KEGG	4514	Cell adhesion molecules (CAMs)	1
63	MARH1_HUMAN	KEGG	4640	Hematopoietic cell lineage	0
64	MARH1_HUMAN	KEGG	5322	Systemic lupus erythematosus	0
65	MARH8_HUMAN	KEGG	4640	Hematopoietic cell lineage	1
66	MARH1_HUMAN	KEGG	4514	Cell adhesion molecules (CAMs)	0
67	MARH8_HUMAN	KEGG	4612	Antigen processing and presentation	1
68	PRKN2_HUMAN	KEGG	5012	Parkinson's disease	68
69	SMUF2_HUMAN	KEGG	4350	TGF-beta signaling pathway	60
70	MARH1_HUMAN	KEGG	4612	Antigen processing and presentation	0
71	NED4L_HUMAN	KEGG	4960	Aldosterone-regulated sodium reabsorption	17
72	MARH9_HUMAN	KEGG	4514	Cell adhesion molecules (CAMs)	1
73	NEDD4_HUMAN	KEGG	4144	Endocytosis	43
74	ZN363_HUMAN	KEGG	5220	Chronic myeloid leukemia	21
75	TRAF6_HUMAN	KEGG	4621	NOD-like receptor signaling pathway	361
76	RAD18_HUMAN	KEGG	3430	Mismatch repair	15
77	RN128_HUMAN	KEGG	4962	Vasopressin-regulated water reabsorption	5
78	TRAF6_HUMAN	KEGG	4622	RIG-I-like receptor signaling pathway	361
79	RAD18_HUMAN	KEGG	3030	DNA replication	15
80	TRI32_HUMAN	KEGG	4120	Ubiquitin mediated proteolysis	8
81	RN125_HUMAN	KEGG	4622	RIG-I-like receptor signaling pathway	12
82	TRI25_HUMAN	KEGG	4622	RIG-I-like receptor signaling pathway	24
83	RAD18_HUMAN	KEGG	3420	Nucleotide excision repair	15
84	ZN363_HUMAN	KEGG	4110	Cell cycle	21
85	SIAH2_HUMAN	KEGG	5200	Pathways in cancer	35
86	BIRC3_HUMAN	KEGG	4660	T cell receptor signaling pathway	31
87	RN138_HUMAN	KEGG	5216	Thyroid cancer	5
88	SCF(SKP2)_HUMAN	KEGG	4110	Cell cycle	0
89	APC(CDH1)_HUMAN	KEGG	4110	Cell cycle	0
90	SCF(SKP2)_HUMAN	KEGG	5200	Pathways in cancer	0
91	SCF(SKP2)_HUMAN	KEGG	5220	Chronic myeloid leukemia	0
92	SCF(SKP2)_HUMAN	KEGG	5219	Bladder cancer	0
93	SCF(SKP2)_HUMAN	KEGG	5222	Small cell lung cancer	0
94	SCF(SKP2)_HUMAN	KEGG	5215	Prostate cancer	0
95	APC(CDH1)_HUMAN	KEGG	4114	Oocyte meiosis	0
96	SCF(BTRC)_HUMAN	KEGG	4660	T cell receptor signaling pathway	0
97	APC(CDC20)_HUMAN	KEGG	4110	Cell cycle	0
98	ECS(SOCS1)_HUMAN	KEGG	4062	Chemokine signaling pathway	0
99	ECS(SOCS1)_HUMAN	KEGG	4662	B cell receptor signaling pathway	0
100	DCX(DET1-COP1)_HUMAN	KEGG	61	Fatty acid biosynthesis	0

No.	E3_ID	Category	Term_ID	Term_Name	No. of proteins recognized by E3 via PPI
1	CBL_HUMAN	COMP	E3Net: rt_191566	Activated FGFR complexed with phosphorylated FRS2, GRB2 and CBL [plasma membrane]	111
2	CBL_HUMAN	COMP	E3Net: cc_2565	CD20-LCK-LYN-FYN-p75/80 complex, (Raji Homo sapiens (Human) B cell line)	111
3	CBL_HUMAN	COMP	E3Net: cc_2563	FGFR2-c-Cbl-Lyn-Fyn complex	111
4	MIB2_HUMAN	COMP	E3Net: cc_3154	Notch2(N-TM)-Notch2(N-EC)-Delta complex	6
5	MIB1_HUMAN	COMP	E3Net: cc_3154	Notch2(N-TM)-Notch2(N-EC)-Delta complex	8
6	XIAP_HUMAN	COMP	E3Net: rt_114318	SMAC:XIAP:Caspase-9 [cytosol]	52
7	XIAP_HUMAN	COMP	E3Net: rt_114305	SMAC:XIAP:Caspase-3 [cytosol]	52
8	MDM2_HUMAN	COMP	E3Net: cc_98	p300-MDM2-p53 protein complex	133
9	MDM2_HUMAN	COMP	E3Net: cc_4	ACTR-p300-PCAF complex	133
10	MIB2_HUMAN	COMP	E3Net: rt_157627	Notch 4 ligand-bound fragment-Notch ligand complex [plasma membrane]	6
11	MIB1_HUMAN	COMP	E3Net: rt_157658	Notch 1 ligand-bound fragment-Notch ligand complex [plasma membrane]	8
12	MIB2_HUMAN	COMP	E3Net: rt_157637	NTM-NEC2-Notch ligand complex [extracellular region]	6
13	MIB2_HUMAN	COMP	E3Net: rt_157638	NTM-NEC3-Notch ligand complex [extracellular region]	6
14	MIB2_HUMAN	COMP	E3Net: rt_157650	Notch 3 ligand-bound fragment-Notch ligand complex [plasma membrane]	6
15	MIB2_HUMAN	COMP	E3Net: rt_157653	NTM-NEC4-Notch ligand complex [extracellular region]	6
16	MIB2_HUMAN	COMP	E3Net: rt_157655	NTM-NEC1-Notch ligand complex [extracellular region]	6
17	MIB2_HUMAN	COMP	E3Net: rt_157658	Notch 1 ligand-bound fragment-Notch ligand complex [plasma membrane]	6
18	MIB2_HUMAN	COMP	E3Net: rt_157630	Notch 2 ligand-bound fragment-Notch ligand complex [plasma membrane]	6
19	MIB1_HUMAN	COMP	E3Net: rt_157627	Notch 4 ligand-bound fragment-Notch ligand complex [plasma membrane]	8
20	MIB1_HUMAN	COMP	E3Net: rt_157630	Notch 2 ligand-bound fragment-Notch ligand complex [plasma membrane]	8
21	MIB1_HUMAN	COMP	E3Net: rt_157637	NTM-NEC2-Notch ligand complex [extracellular region]	8
22	MIB1_HUMAN	COMP	E3Net: rt_157638	NTM-NEC3-Notch ligand complex [extracellular region]	8
23	MIB1_HUMAN	COMP	E3Net: rt_157650	Notch 3 ligand-bound fragment-Notch ligand complex [plasma membrane]	8
24	MIB1_HUMAN	COMP	E3Net: rt_157653	NTM-NEC4-Notch ligand complex [extracellular region]	8
25	MIB1_HUMAN	COMP	E3Net: rt_157655	NTM-NEC1-Notch ligand complex [extracellular region]	8
26	XIAP_HUMAN	COMP	E3Net: rt_114391	SMAC:XIAP [cytosol]	52
27	XIAP_HUMAN	COMP	E3Net: rt_114304	XIAP:Caspase-3 [cytosol]	52
28	XIAP_HUMAN	COMP	E3Net: rt_114317	XIAP:Caspase-9 [cytosol]	52
29	XIAP_HUMAN	COMP	E3Net: rt_114353	SMAC:XIAP:Caspase-7 [cytosol]	52
30	CBLB_HUMAN	COMP	E3Net: rt_212703	Activated EGFR:Phospho-PLC-gamma1 [plasma membrane]	15
31	CBLB_HUMAN	COMP	E3Net: rt_212717	Activated EGFR:PLC-gamma1 [plasma membrane]	15
32	WWP1_HUMAN	COMP	E3Net: rt_173476	TGF-beta 1:type II receptor:Phospho-type I receptor:I-SMAD complex [plasma membrane]	17
33	WWP2_HUMAN	COMP	E3Net: cc_2801	OCT4-SOX2 DNA-protein complex	39
34	RNF6_HUMAN	COMP	E3Net: cc_2159	AR-AKT-APPL complex	1
35	RNF4_HUMAN	COMP	E3Net: cc_1055	ZNF198-PML complex	18
36	MARH8_HUMAN	COMP	E3Net: rt_203478	HLA-DR [plasma membrane]	1
37	MARH1_HUMAN	COMP	E3Net: rt_203478	HLA-DR [plasma membrane]	0
38	MARH8_HUMAN	COMP	E3Net: rt_203463	MHC Class II bearing antigen peptide [plasma membrane]	1
39	MARH1_HUMAN	COMP	E3Net: rt_203463	MHC Class II bearing antigen peptide [plasma membrane]	0
40	MARH8_HUMAN	COMP	E3Net: rt_202266	Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane]	1
41	MARH8_HUMAN	COMP	E3Net: rt_203494	Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane]	1
42	MARH8_HUMAN	COMP	E3Net: rt_202157	Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane]	1
43	MARH8_HUMAN	COMP	E3Net: rt_202154	Antigen-bearing MHC Class II : TCR complex:CD4:Lck pY505 [plasma membrane]	1
44	MARH8_HUMAN	COMP	E3Net: rt_202345	phospho tyrosine ZAP-70 [plasma membrane]	1
45	MARH8_HUMAN	COMP	E3Net: rt_202181	Activated ZAP-70 [plasma membrane]	1
46	MARH8_HUMAN	COMP	E3Net: rt_202330	ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane]	1
47	MARH1_HUMAN	COMP	E3Net: rt_202157	Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane]	0
48	MARH1_HUMAN	COMP	E3Net: rt_203494	Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane]	0
49	MARH1_HUMAN	COMP	E3Net: rt_202154	Antigen-bearing MHC Class II : TCR complex:CD4:Lck pY505 [plasma membrane]	0
50	MARH1_HUMAN	COMP	E3Net: rt_202266	Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane]	0
51	MARH1_HUMAN	COMP	E3Net: rt_202345	phospho tyrosine ZAP-70 [plasma membrane]	0
52	MARH1_HUMAN	COMP	E3Net: rt_202181	Activated ZAP-70 [plasma membrane]	0
53	MARH1_HUMAN	COMP	E3Net: rt_202330	ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane]	0
54	SMUF2_HUMAN	COMP	E3Net: cc_1783	TGF-beta receptor I-SMAD7-SMURF1 complex	60
55	SMUF2_HUMAN	COMP	E3Net: cc_2997	SMAD7-SMURF1-TGF-beta receptor complex	60
56	SMUF1_HUMAN	COMP	E3Net: rt_202644	I-Smad:Phospho-R-Smad1/5/8 [cytosol]	46
57	TRI25_HUMAN	COMP	E3Net: cc_2717	Ubiquitin E3 ligase (TRIM25, DDX58)	24
58	BIRC3_HUMAN	COMP	E3Net: cc_2053	BCL10-MALT1 complex	31
59	BIRC3_HUMAN	COMP	E3Net: cc_2752	CARMA1-BCL10-MALT1 complex	31
60	TRAF6_HUMAN	COMP	E3Net: rt_202507	TAK1/TAB2 complex bound to TRAF6/CBM complex [plasma membrane]	361
61	BIRC3_HUMAN	COMP	E3Net: rt_202468	MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane]	31
62	BIRC3_HUMAN	COMP	E3Net: cc_2753	FYB-CARMA1-BCL-10-MALT1 complex	31
63	RAD18_HUMAN	COMP	E3Net: cc_2797	PCNA-CHL12-RFC2-5 complex	15
64	BIRC3_HUMAN	COMP	E3Net: cc_2745	Ubiquitin ligase complex (TRAF6, TAB2, MALT1, UEV1A, BCL10)	31
65	BIRC3_HUMAN	COMP	E3Net: rt_202471	TRAF6 trimer bound to CBM complex [plasma membrane]	31
66	RAD18_HUMAN	COMP	E3Net: rt_174449	RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end duplex:PCNA homotrimer [nucleoplasm]	15
67	RAD18_HUMAN	COMP	E3Net: GO:0005663	DNA replication factor C complex	15
68	BIRC3_HUMAN	COMP	E3Net: rt_202456	Ub-TRAF6 trimer bound to CBM complex [plasma membrane]	31
69	BIRC3_HUMAN	COMP	E3Net: rt_202507	TAK1/TAB2 complex bound to TRAF6/CBM complex [plasma membrane]	31
70	SMUF2_HUMAN	COMP	E3Net: cc_2996	SMAD7-SMURF1 complex	60
71	RN128_HUMAN	COMP	E3Net: rt_194912	Inactivated RhoGTPase:GDP:GDI complex [cytosol]	5
72	TRAF6_HUMAN	COMP	E3Net: cc_2743	TRAF6-MALT1 complex	361
73	TRAF6_HUMAN	COMP	E3Net: cc_748	TRAF6-TAK1 complex	361
74	RAD18_HUMAN	COMP	E3Net: rt_68471	RFC Heteropentamer:RNA primer-DNA primer:origin duplex:PCNA homotrimer [nucleoplasm]	15
75	SIAH1_HUMAN	COMP	E3Net: cc_521	Polycystin-1-E-cadherin-beta-catenin complex	43
76	HERC5_HUMAN	COMP	E3Net: rt_74193	nucleoside diphosphate kinase A,B heterohexamer [cytosol]	60
77	RN125_HUMAN	COMP	E3Net: cc_2717	Ubiquitin E3 ligase (TRIM25, DDX58)	12
78	TRI11_HUMAN	COMP	E3Net: cc_2803	PAX6-SOX2 DNA-protein complex	2
79	RN138_HUMAN	COMP	E3Net: cc_3155	Bipartite complex (TFC4, CTNNB1)	5
80	RN135_HUMAN	COMP	E3Net: cc_2717	Ubiquitin E3 ligase (TRIM25, DDX58)	3
81	SMUF1_HUMAN	COMP	E3Net: rt_173476	TGF-beta 1:type II receptor:Phospho-type I receptor:I-SMAD complex [plasma membrane]	46
82	SMUF2_HUMAN	COMP	E3Net: rt_173511	Phospho-R-SMAD:CO-SMAD complex [nucleoplasm]	60
83	SMUF2_HUMAN	COMP	E3Net: cc_3038	SMAD2-SMAD4-FAST1 complex	60
84	SMUF2_HUMAN	COMP	E3Net: cc_2834	SMAD4-SMAD2-SMAD3 complex	60
85	SMUF2_HUMAN	COMP	E3Net: rt_171175	Phospho-R-SMAD:CO-SMAD complex [cytosol]	60
86	PIAS2_HUMAN	COMP	E3Net: cc_60	interferon-stimulated gene factor 3 transcription complex ISGF3	95
87	TRAF6_HUMAN	COMP	E3Net: rt_209578	NGF ligand:p75NTR:RIP2 [plasma membrane]	361
88	SIAH1_HUMAN	COMP	E3Net: cc_522	Polycystin-1-E-cadherin-beta-catenin-Flotillin-2 complex	43
89	NED4L_HUMAN	COMP	E3Net: rt_171180	TGF-beta 1:type II receptor:Phospho-type I receptor:SARA:Phospho-R-SMAD complex [early endosome membrane]	17
90	NED4L_HUMAN	COMP	E3Net: rt_171266	TGF-beta 1:type II receptor:Phospho-type I receptor:SARA:R-SMAD complex [early endosome membrane]	17
91	NHLC1_HUMAN	COMP	E3Net: GO:0043033	isoamylase complex	5
92	HECD3_HUMAN	COMP	E3Net: rt_376352	Lysosome vesicle docking and fusion complex [lysosomal membrane, Golgi-associated vesicle membrane]	1
93	HECW1_HUMAN	COMP	E3Net: GO:0019717	synaptosome	8
94	SCF(BTRC)_HUMAN	COMP	E3Net: rt_168130	IkBs:NFkB Complex [cytosol]	0
95	BCR(SPOP)_HUMAN	COMP	E3Net: cc_2700	ER-alpha-c-Jun complex	0
96	APC(CDH1)_HUMAN	COMP	E3Net: rt_174107	cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol]	0
97	BCR(SPOP)_HUMAN	COMP	E3Net: cc_2699	ER-alpha-GRIP1-c-Jun complex	0
98	APC(CDH1)_HUMAN	COMP	E3Net: rt_174248	multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol]	0
99	SCF(SKP2)_HUMAN	COMP	E3Net: cc_3015	p27-cyclinE-Cdk2 - Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) complex	0
100	ECS(ASB9)_HUMAN	COMP	E3Net: rt_200374	creatine kinase BM dimer [cytosol]	0
101	SCF(FBXW7)_HUMAN	COMP	E3Net: rt_68377	Cyclin E:phospho-Cdk2 Complex [nucleoplasm]	0
102	SCF(FBXW7)_HUMAN	COMP	E3Net: rt_157594	Cyclin E:Cdk2 complex [cytosol]	0
103	SCF(FBXW7)_HUMAN	COMP	E3Net: rt_188362	Cyclin E:Phosho-Cdk2 (Thr 160) [nucleoplasm]	0
104	DCX(TRUSS)_HUMAN	COMP	E3Net: cc_3052	MYC-MAX complex	0
105	SCF(FBXO7)_HUMAN	COMP	E3Net: GO:0031616	spindle pole centrosome	0
106	SCF(FBXO6)_HUMAN	COMP	E3Net: cc_2714	Ubiquitin E3 ligase (CHEK1, CUL1)	0
107	SCF(FBXO6)_HUMAN	COMP	E3Net: cc_2171	Ubiquitin E3 ligase (CHEK1, CUL4A)	0
108	SCF(FBXW7)_HUMAN	COMP	E3Net: rt_188391	Cyclin E:phospho-Cdk2 (Thr 160):phospho-Rb [nucleoplasm]	0
109	SCF(FBXW7)_HUMAN	COMP	E3Net: rt_188373	Cyclin E:Phospho-Cdk2(Thr160):Rb complex [nucleoplasm]	0
110	SCF(FBXW11)_HUMAN	COMP	E3Net: rt_193938	IkB(alpha):NF-kB complex [cytosol]	0
111	BRCA1-BARD1_HUMAN	COMP	E3Net: cc_2686	BRCA1-core RNA polymerase II complex	0
112	SCF(FBXW11)_HUMAN	COMP	E3Net: rt_168130	IkBs:NFkB Complex [cytosol]	0
113	SCF(FBXW11)_HUMAN	COMP	E3Net: cc_2187	Ubiquitin E3 ligase (NFKBIA, FBXW11, BTRC, CUL1, SKP1A)	0
114	SCF(FBXO18)_HUMAN	COMP	E3Net: cc_2191	Ubiquitin E3 ligase (FBXO18, SKP1A, CUL1, RBX1)	0
115	E4-E1B-ElonginBC-CUL5_HUMAN	COMP	E3Net: cc_1189	DNA double-strand break end-joining complex	0
116	VIF-CUL5-ElonginBC-RBX2_HUMAN	COMP	E3Net: GO:0030895	apolipoprotein B mRNA editing enzyme complex	0

No.	E3_ID	Category	Term_ID	Term_Name	No. of proteins recognized by E3 via PPI
1	PPD_HUMAN	KWDI	KW-0907	Parkinson disease	0
2	CBL_HUMAN	KWDI	KW-0656	Proto-oncogene	111
3	CBL_HUMAN	KWDI	KW-0989	Craniosynostosis	111
4	KPC_HUMAN	OMIM	610755	MULTIPLE ENDOCRINE NEOPLASIA, TYPE IV; MEN4	0
5	CBL_HUMAN	OMIM	606764	GASTROINTESTINAL STROMAL TUMOR; GIST	111
6	MDM2_HUMAN	OMIM	180849	RUBINSTEIN-TAYBI SYNDROME; RSTS	133
7	MIB2_HUMAN	OMIM	277300	SPONDYLOCOSTAL DYSOSTOSIS 1, AUTOSOMAL RECESSIVE; SCDO1	6
8	MIB1_HUMAN	OMIM	277300	SPONDYLOCOSTAL DYSOSTOSIS 1, AUTOSOMAL RECESSIVE; SCDO1	8
9	ARI2_HUMAN	OMIM	607847	NEUTROPENIA, NONIMMUNE CHRONIC IDIOPATHIC, OF ADULTS	29
10	ARI2_HUMAN	OMIM	202700	NEUTROPENIA, SEVERE CONGENITAL, AUTOSOMAL DOMINANT 1; SCN1	29
11	RO52_HUMAN	OMIM	610755	MULTIPLE ENDOCRINE NEOPLASIA, TYPE IV; MEN4	17
12	RAG1_HUMAN	OMIM	609889	ALPHA/BETA T-CELL LYMPHOPENIA WITH GAMMA/DELTA T-CELL EXPANSION, SEVERECYTOMEGALOVIRUS INFECTION, AND AUTOIMMUNITY	6
13	MARH1_HUMAN	OMIM	181000	SARCOIDOSIS, SUSCEPTIBILITY TO, 1; SS1	0
14	MARH8_HUMAN	OMIM	181000	SARCOIDOSIS, SUSCEPTIBILITY TO, 1; SS1	1
15	MARH8_HUMAN	OMIM	180300	RHEUMATOID ARTHRITIS; RA	1
16	MARH1_HUMAN	OMIM	180300	RHEUMATOID ARTHRITIS; RA	0
17	MARH8_HUMAN	OMIM	126200	MULTIPLE SCLEROSIS, SUSCEPTIBILITY TO; MS	1
18	MARH1_HUMAN	OMIM	126200	MULTIPLE SCLEROSIS, SUSCEPTIBILITY TO; MS	0
19	PRKN2_HUMAN	KWDI	KW-0907	Parkinson disease	68
20	FANCL_HUMAN	KWDI	KW-0923	Fanconi anemia	5
21	RN180_HUMAN	OMIM	609637	HOLOPROSENCEPHALY 5; HPE5	0
22	RC3H1_HUMAN	OMIM	607594	ICOS DEFICIENCY	0
23	HERC2_HUMAN	OMIM	278700	XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP A; XPA	4
24	UBE4B_HUMAN	OMIM	109150	MACHADO-JOSEPH DISEASE; MJD	14
25	NOSIP_HUMAN	OMIM	133100	ERYTHROCYTOSIS, FAMILIAL, 1	0
26	SH3R1_HUMAN	OMIM	241200	BARTTER SYNDROME, ANTENATAL, TYPE 2	7
27	RNF31_HUMAN	OMIM	300200	ADRENAL HYPOPLASIA, CONGENITAL; AHC	2
28	CNOT4_HUMAN	OMIM	300534	MENTAL RETARDATION, X-LINKED, SYNDROMIC, JARID1C-RELATED	17
29	RNF31_HUMAN	OMIM	300018	DOSAGE-SENSITIVE SEX REVERSAL; DSS	2
30	TRI37_HUMAN	OMIM	253250	MULIBREY NANISM	18
31	RN111_HUMAN	OMIM	612229	COLORECTAL CANCER, SUSCEPTIBILITY TO, 3; CRCS3	17
32	TRAF6_HUMAN	KWDI	KW-0907	Parkinson disease	361
33	TRI63_HUMAN	OMIM	115210	CARDIOMYOPATHY, FAMILIAL RESTRICTIVE, 1; RCM1	29
34	TRI33_HUMAN	OMIM	175050	JUVENILE POLYPOSIS/HEREDITARY HEMORRHAGIC TELANGIECTASIA SYNDROME;JPHT	26
35	TRI63_HUMAN	OMIM	611880	CARDIOMYOPATHY, DILATED, 2A; CMD2A	29
36	HECD3_HUMAN	OMIM	609823	DEAFNESS, AUTOSOMAL RECESSIVE 28; DFNB28	1
37	PZRN3_HUMAN	OMIM	608931	MYASTHENIC SYNDROME, CONGENITAL, ASSOCIATED WITH ACETYLCHOLINE RECEPTORDEFICIENCY	2
38	FANCL_HUMAN	OMIM	608053	ELECTRON TRANSFER FLAVOPROTEIN, ALPHA POLYPEPTIDE; ETFA	5
39	SCF(SKP2)_HUMAN	KWDI	KW-0656	Proto-oncogene	0
40	DCX(TRUSS)_HUMAN	OMIM	113970	BURKITT LYMPHOMA; BL	0
41	BCR(KLHL8)_HUMAN	OMIM	208150	FETAL AKINESIA DEFORMATION SEQUENCE; FADS	0
42	APC(CDC20)_HUMAN	OMIM	257300	MOSAIC VARIEGATED ANEUPLOIDY SYNDROME; MVA	0
43	APC(CDC20)_HUMAN	OMIM	176430	PREMATURE CHROMATID SEPARATION TRAIT; PCS	0
44	BCR(KLHL17)_HUMAN	OMIM	611092	MENTAL RETARDATION, AUTOSOMAL RECESSIVE 6; MRT6	0

No.	E3_ID	Category	Term_ID	Term_Name	No. of proteins recognized by E3 via PPI
1	CBL_HUMAN	GOBP	GO:0007167	enzyme linked receptor protein signaling pathway	111
2	CBL_HUMAN	GOBP	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	111
3	CBL_HUMAN	GOBP	GO:0023052	signaling	111
4	CBL_HUMAN	GOBP	GO:0006468	protein amino acid phosphorylation	111
5	CBL_HUMAN	GOBP	GO:0007166	cell surface receptor linked signaling pathway	111
6	CBL_HUMAN	GOBP	GO:0023033	signaling pathway	111
7	CBL_HUMAN	GOBP	GO:0043687	post-translational protein modification	111
8	CBL_HUMAN	GOBP	GO:0016310	phosphorylation	111
9	CBL_HUMAN	GOBP	GO:0006793	phosphorus metabolic process	111
10	CBL_HUMAN	GOBP	GO:0006796	phosphate metabolic process	111
11	CBL_HUMAN	GOBP	GO:0008283	cell proliferation	111
12	CBL_HUMAN	GOBP	GO:0006464	protein modification process	111
13	CBL_HUMAN	GOBP	GO:0008284	positive regulation of cell proliferation	111
14	CBL_HUMAN	GOBP	GO:0048518	positive regulation of biological process	111
15	CBL_HUMAN	GOBP	GO:0043412	macromolecule modification	111
16	CBL_HUMAN	GOBP	GO:0007165	signal transduction	111
17	CBL_HUMAN	GOBP	GO:0023060	signal transmission	111
18	CBL_HUMAN	GOBP	GO:0023046	signaling process	111
19	CBL_HUMAN	GOBP	GO:0006928	cellular component movement	111
20	CBL_HUMAN	GOBP	GO:0018108	peptidyl-tyrosine phosphorylation	111
21	CBL_HUMAN	GOBP	GO:0018212	peptidyl-tyrosine modification	111
22	CBL_HUMAN	GOBP	GO:0042127	regulation of cell proliferation	111
23	CBL_HUMAN	GOBP	GO:0044267	cellular protein metabolic process	111
24	CBL_HUMAN	GOBP	GO:0023014	signal transmission via phosphorylation event	111
25	CBL_HUMAN	GOBP	GO:0007243	intracellular protein kinase cascade	111
26	CBL_HUMAN	GOBP	GO:0048522	positive regulation of cellular process	111
27	CBL_HUMAN	KWBP	KW-0597	Phosphoprotein	111
28	CBL_HUMAN	GOBP	GO:0018193	peptidyl-amino acid modification	111
29	CBL_HUMAN	GOBP	GO:0008543	fibroblast growth factor receptor signaling pathway	111
30	CBL_HUMAN	GOBP	GO:0050794	regulation of cellular process	111
31	CBL_HUMAN	GOBP	GO:0019538	protein metabolic process	111
32	CBL_HUMAN	GOBP	GO:0050789	regulation of biological process	111
33	CBL_HUMAN	GOBP	GO:0023034	intracellular signaling pathway	111
34	CBL_HUMAN	GOBP	GO:0007275	multicellular organismal development	111
35	CBL_HUMAN	GOBP	GO:0035556	intracellular signal transduction	111
36	CBL_HUMAN	GOBP	GO:0051272	positive regulation of cellular component movement	111
37	CBL_HUMAN	GOBP	GO:0035468	positive regulation of signaling pathway	111
38	CBL_HUMAN	GOBP	GO:0065007	biological regulation	111
39	CBL_HUMAN	GOBP	GO:0051270	regulation of cellular component movement	111

No.	E3_ID	Category	Term_ID	Term_Name	No. of proteins recognized by E3 via PPI
1	CBL_HUMAN	GOCC	GO:0005887	integral to plasma membrane	111
2	CBL_HUMAN	GOCC	GO:0031226	intrinsic to plasma membrane	111
3	CBL_HUMAN	GOCC	GO:0005886	plasma membrane	111
4	CBL_HUMAN	KWCC	KW-0472	Membrane	111
5	CBL_HUMAN	GOCC	GO:0044459	plasma membrane part	111
6	CBL_HUMAN	GOCC	GO:0005829	cytosol	111
7	CBL_HUMAN	GOCC	GO:0016020	membrane	111
8	CBL_HUMAN	GOCC	GO:0043235	receptor complex	111
9	PRC1_HUMAN	GOCC	GO:0000786	nucleosome	7
10	PRC1_HUMAN	KWCC	KW-0544	Nucleosome core	7
11	PRC1_HUMAN	GOCC	GO:0032993	protein-DNA complex	7
12	PRC1_HUMAN	KWCC	KW-0158	Chromosomal protein	7
13	PRC1_HUMAN	GOCC	GO:0000785	chromatin	7
14	PRC1_HUMAN	GOCC	GO:0044427	chromosomal part	7
15	PRC1_HUMAN	GOCC	GO:0005694	chromosome	7
16	PRC1_HUMAN	GOCC	GO:0043232	intracellular non-membrane-bounded organelle	7
17	PRC1_HUMAN	GOCC	GO:0043228	non-membrane-bounded organelle	7
18	PRC1_HUMAN	KWCC	KW-0539	Nucleus	7
19	PRC1_HUMAN	GOCC	GO:0005634	nucleus	7
20	PRC1_HUMAN	GOCC	GO:0044446	intracellular organelle part	7
21	PRC1_HUMAN	GOCC	GO:0044422	organelle part	7
22	MDM2_HUMAN	GOCC	GO:0005654	nucleoplasm	133
23	XIAP_HUMAN	GOCC	GO:0005829	cytosol	52
24	MDM2_HUMAN	KWCC	KW-0539	Nucleus	133
25	MDM2_HUMAN	GOCC	GO:0031981	nuclear lumen	133
26	CHIP_HUMAN	KWCC	KW-0963	Cytoplasm	44
27	MDM2_HUMAN	GOCC	GO:0005634	nucleus	133
28	CHIP_HUMAN	GOCC	GO:0005634	nucleus	44
29	CHIP_HUMAN	GOCC	GO:0043231	intracellular membrane-bounded organelle	44
30	CHIP_HUMAN	GOCC	GO:0043227	membrane-bounded organelle	44
31	CHIP_HUMAN	GOCC	GO:0005737	cytoplasm	44
32	MDM2_HUMAN	GOCC	GO:0044451	nucleoplasm part	133
33	MDM2_HUMAN	GOCC	GO:0070013	intracellular organelle lumen	133
34	PRC1_HUMAN	GOCC	GO:0032991	macromolecular complex	7
35	MDM2_HUMAN	GOCC	GO:0043233	organelle lumen	133
36	MDM2_HUMAN	GOCC	GO:0031974	membrane-enclosed lumen	133
37	CHIP_HUMAN	GOCC	GO:0044424	intracellular part	44
38	CHIP_HUMAN	GOCC	GO:0043229	intracellular organelle	44
39	CHIP_HUMAN	GOCC	GO:0043226	organelle	44

No.	E3_ID	Category	Term_ID	Term_Name	No. of proteins recognized by E3 via PPI
1	CBL_HUMAN	KWMF	KW-0829	Tyrosine-protein kinase	111
2	CBL_HUMAN	GOMF	GO:0004713	protein tyrosine kinase activity	111
3	CBL_HUMAN	GOMF	GO:0004714	transmembrane receptor protein tyrosine kinase activity	111
4	CBL_HUMAN	GOMF	GO:0019199	transmembrane receptor protein kinase activity	111
5	CBL_HUMAN	GOMF	GO:0004672	protein kinase activity	111
6	CBL_HUMAN	GOMF	GO:0016773	phosphotransferase activity, alcohol group as acceptor	111
7	CBL_HUMAN	GOMF	GO:0005515	protein binding	111
8	CBL_HUMAN	GOMF	GO:0016301	kinase activity	111
9	CBL_HUMAN	GOMF	GO:0019838	growth factor binding	111
10	CBL_HUMAN	KWMF	KW-0418	Kinase	111
11	CBL_HUMAN	GOMF	GO:0016772	transferase activity, transferring phosphorus-containing groups	111
12	CBL_HUMAN	GOMF	GO:0004871	signal transducer activity	111
13	CBL_HUMAN	GOMF	GO:0060089	molecular transducer activity	111
14	CBL_HUMAN	KWMF	KW-0067	ATP-binding	111
15	CBL_HUMAN	GOMF	GO:0004888	transmembrane receptor activity	111
16	CBL_HUMAN	KWMF	KW-0808	Transferase	111
17	CBL_HUMAN	KWMF	KW-0547	Nucleotide-binding	111
18	CBL_HUMAN	GOMF	GO:0005524	ATP binding	111
19	CBL_HUMAN	GOMF	GO:0032559	adenyl ribonucleotide binding	111
20	CBL_HUMAN	GOMF	GO:0030554	adenyl nucleotide binding	111
21	CBL_HUMAN	GOMF	GO:0001883	purine nucleoside binding	111
22	CBL_HUMAN	GOMF	GO:0001882	nucleoside binding	111
23	CBL_HUMAN	GOMF	GO:0016740	transferase activity	111
24	CBL_HUMAN	GOMF	GO:0004716	receptor signaling protein tyrosine kinase activity	111
25	CBL_HUMAN	GOMF	GO:0004872	receptor activity	111
26	CBL_HUMAN	GOMF	GO:0005057	receptor signaling protein activity	111
27	CBL_HUMAN	KWMF	KW-0675	Receptor	111
28	CBL_HUMAN	GOMF	GO:0032555	purine ribonucleotide binding	111
29	CBL_HUMAN	GOMF	GO:0032553	ribonucleotide binding	111
30	CBL_HUMAN	GOMF	GO:0004715	non-membrane spanning protein tyrosine kinase activity	111
31	CBL_HUMAN	GOMF	GO:0017076	purine nucleotide binding	111
32	CBL_HUMAN	GOMF	GO:0005007	fibroblast growth factor receptor activity	111
33	CBL_HUMAN	GOMF	GO:0017134	fibroblast growth factor binding	111
34	CBL_HUMAN	GOMF	GO:0000166	nucleotide binding	111
35	CBL_HUMAN	GOMF	GO:0070851	growth factor receptor binding	111
36	CBL_HUMAN	GOMF	GO:0005011	macrophage colony stimulating factor receptor activity	111
37	CBL_HUMAN	GOMF	GO:0005161	platelet-derived growth factor receptor binding	111
38	CBL_HUMAN	GOMF	GO:0060090	molecular adaptor activity	111
39	CBL_HUMAN	GOMF	GO:0005102	receptor binding	111

No.	E3_ID	Category	Term_ID	Term_Name	No. of proteins recognized by E3 via PPI
1	CBL_HUMAN	PFAM	PF07714	Pkinase_Tyr	111
2	CBL_HUMAN	KWDOM	KW-0727	SH2 domain	111
3	CBL_HUMAN	PFAM	PF00017	SH2	111
4	CBL_HUMAN	PFAM	PF00018	SH3_1	111
5	CBL_HUMAN	KWDOM	KW-0732	Signal	111
6	CBL_HUMAN	KWDOM	KW-0393	Immunoglobulin domain	111
7	CBL_HUMAN	KWDOM	KW-0728	SH3 domain	111
8	CBL_HUMAN	PFAM	PF07679	I-set	111
9	CBL_HUMAN	KWDOM	KW-0677	Repeat	111
10	KPC_HUMAN	PFAM	PF02234	CDI	0
11	CBL_HUMAN	PFAM	PF00041	fn3	111
12	PRC1_HUMAN	PFAM	PF00125	Histone	7
13	MIB2_HUMAN	PFAM	PF07657	MNNL	6
14	MIB1_HUMAN	PFAM	PF07657	MNNL	8
15	CBLB_HUMAN	KWDOM	KW-0727	SH2 domain	15
16	TTC3_HUMAN	PFAM	PF00433	Pkinase_C	7
17	MIB2_HUMAN	PFAM	PF00008	EGF	6
18	MIB2_HUMAN	PFAM	PF01414	DSL	6
19	TTC3_HUMAN	PFAM	PF00169	PH	7
20	MIB1_HUMAN	PFAM	PF01414	DSL	8
21	MIB1_HUMAN	PFAM	PF00008	EGF	8
22	RNF8_HUMAN	PFAM	PF00125	Histone	13
23	TTC3_HUMAN	PFAM	PF00069	Pkinase	7
24	WWP1_HUMAN	PFAM	PF07710	P53_tetramer	17
25	MDM2_HUMAN	PFAM	PF09030	Creb_binding	133
26	CBLB_HUMAN	PFAM	PF00017	SH2	15
27	RO52_HUMAN	PFAM	PF10401	IRF-3	17
28	MDM2_HUMAN	PFAM	PF06001	DUF902	133
29	CBLB_HUMAN	PFAM	PF07714	Pkinase_Tyr	15
30	ITCH_HUMAN	PFAM	PF03957	Jun	47
31	RO52_HUMAN	PFAM	PF00605	IRF	17
32	MIB2_HUMAN	KWDOM	KW-0245	EGF-like domain	6
33	MDM2_HUMAN	PFAM	PF02172	KIX	133
34	HLTF_HUMAN	PFAM	PF02747	PCNA_C	17
35	ITCH_HUMAN	PFAM	PF00170	bZIP_1	47
36	RAG1_HUMAN	PFAM	PF10426	zf-RAG1	6
37	M3K1_HUMAN	PFAM	PF00170	bZIP_1	133
38	MDM2_HUMAN	KWDOM	KW-0103	Bromodomain	133
39	HLTF_HUMAN	PFAM	PF00705	PCNA_N	17