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Network analysis: Case study 2 - The given list contains only 3 E3 ligases (no Ubi-substrate proteins; no interacting proteins).

(In this case study, the regulatory network, which contains interactions between all E3 ligases and all possible Ubi-subtrate proteins, will be constructed for the investigation)

Case Study 1: The given list contains 20 substrate proteins, wherein 4 E3 ligases, 14 Ubi-substrate proteins, and 3 interacting proteins. Case Study 2: The given list contains only 3 E3 ligases (no Ubi-substrate proteins; no substrate proteins).

 

The details of the list as described in the table below:

No.	ID	AC	Gene Name	Anotation	E3: group-type/ UbiSubstrate: Ubi-Sites	PubMed Reference
1	NEDD4_HUMAN	P46934	NEDD4	E3 ligase	E3 HECT-type	19808888; 20086093; 19953087; 15013426; 19193720; 18286479; 12907674; 19125695; 17592138; 17137798; 15060076; 19864419; 20855896; 17996703; 21338354; 21320486; 21212261; 20159449; 18772139; 19787053; 19797085; 19054764; 11598133; 15703212; 15082780; 20559325; 15581898
2	CHIP_HUMAN	Q9UNE7	STUB1	E3 ligase	E3 Other-type	17525155; 17873020; 18381433; 18655187; 18313385; 19103148; 19741096; 18922468; 18955503; 19706771; 15466472; 19642705; 19536328; 19020010; 19483080; 19153604; 19465479; 19406989; 15538384; 17178836; 16740632; 16280320; 14612456; 15761032; 21358815; 19940151; 21124777; 20924358; 19940115; 19913553; 20588253; 17963781; 20724525; 20075607; 17324930; 16940184; 16207813; 11557750; 12297498; 15781469
3	PELI2_HUMAN	Q9HAT8	PELI2	E3 ligase	E3 RING-type	16884718; 17997719

Case Study 1: The given list contains 21 substrate proteins, wherein 4 E3 ligases, 14 Ubi-substrate proteins, and 3 interacting proteins.

Case Study 2: The given list contains only 3 E3 ligases (no Ubi-substrate proteins; no interacting proteins).