UniprotKB/SwissProt ID: PELI2_HUMAN (Q9HAT8)
Gene Name: PELI2
Organism: Homo sapiens (Human).
Function: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7- dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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PDB :
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