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Protein Name: Anaphase-promoting complex subunit 10

UniprotKB/SwissProt ID: APC10_HUMAN (Q9UM13)

Gene Name: ANAPC10

Synonyms: APC10

Organism: Homo sapiens (Human).

Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

PDB :
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Graphical Visualization of Ubiquitination Sites:
Overview of Protein Ubiquitination Sites with Functional and Structural Information
InterPro ID Domain
IPR004939
IPR008979


The ubiquitination sites of APC10_HUMAN

No. Position Ubiquitinated Peptide Secondary Structure Solvent Accessibility Substrate Motifs PubMed ID
114PPGADP K QLERTG CCCCCC H HHHHCC 68.97%21890473
293ESYTPS K ISVRVG CCCCCE E EEEEEC 39.96%21906983
3169EESSIG K FPRCTT CCCCCC C CCCCCC 50.99%2189047

The interacting network mediated by proteins: APC10_HUMAN

Metabolic pathway:
Kegg map ID Pathway
map03008Ribosome biogenesis in eukaryotes