UbiNet

Protein Name: Anaphase-promoting complex subunit 1

UniprotKB/SwissProt ID: APC1_HUMAN (Q9H1A4)

Gene Name: ANAPC1

Synonyms: TSG24

Organism: Homo sapiens (Human).

Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

Graphical Visualization of Ubiquitination Sites:

Overview of Protein Ubiquitination Sites with Functional and Structural Information

The ubiquitination sites of APC1_HUMAN

No.	Position	Ubiquitinated Peptide	Secondary Structure	Solvent Accessibility	Substrate Motifs	PubMed ID
1	69	EVTIHE K QKESWQ		53.13%		21906983
2	140	SQDKSE K AYSSNE		60.77%		21906983
3	275	WTLRRV K SEEENV		50.79%		21906983
4	310	HLRSLS K GDSPVT		72.53%		21890473
5	429	KNSQAS K VFITSD		44.15%		21906983
6	477	VTNIPA K DAAPVE		42.41%		21906983
7	694	SPVIAP K KARPSE		50.47%		21906983
8	905	ITIAPQ K LQVEQE		39.57%		21906983
9	1066	HEFIEE K ENRLLQ		47.72%		21906983
10	1709	AGQLSY K EDPMGW		52.87%		2190698

The interacting network mediated by proteins: APC1_HUMAN

Metabolic pathway:

Kegg map ID	Pathway
map03008	Ribosome biogenesis in eukaryotes

Menu: