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Protein Name: Anaphase-promoting complex subunit 4

UniprotKB/SwissProt ID: APC4_HUMAN (Q9UJX5)

Gene Name: ANAPC4

Synonyms: APC4

Organism: Homo sapiens (Human).

Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

Graphical Visualization of Ubiquitination Sites:
Overview of Protein Ubiquitination Sites with Functional and Structural Information


The ubiquitination sites of APC4_HUMAN

No. Position Ubiquitinated Peptide Secondary Structure Solvent Accessibility Substrate Motifs PubMed ID
1468LYNRKG K YFNVER   50.10%2189047

The interacting network mediated by proteins: APC4_HUMAN

Metabolic pathway:
Kegg map ID Pathway
map03008Ribosome biogenesis in eukaryotes