UbiNet

Protein Name: Anaphase-promoting complex subunit 5

UniprotKB/SwissProt ID: APC5_HUMAN (Q9UJX4)

Gene Name: ANAPC5

Synonyms: APC5

Organism: Homo sapiens (Human).

Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

Graphical Visualization of Ubiquitination Sites:

Overview of Protein Ubiquitination Sites with Functional and Structural Information

The ubiquitination sites of APC5_HUMAN

No.	Position	Ubiquitinated Peptide	Secondary Structure	Solvent Accessibility	Substrate Motifs	PubMed ID
1	167	YFQNGE K KTVEDA		55.96%		21906983
2	168	FQNGEK K TVEDAD		54.20%		21906983
3	224	QQASLL K NDETKA		68.59%		21906983
4	229	LKNDET K ALTPAS		39.07%		21890473
5	238	TPASLQ K ELNNLL		70.26%		21890473
6	245	ELNNLL K FNPDFA		46.38%		21906983
7	289	LTGAES K SNGEEG		39.17%		21890473
8	366	LLEHSV K KAVHFG		37.72%		21906983
9	393	QRAFAG K TANKLM		40.82%		21906983
10	397	AGKTAN K LMDALK		42.60%		21906983
11	403	KLMDAL K DSDLLH		57.83%		21890473
12	524	RAMNDG K YHLADS		32.15%		21906983
13	547	IEGVYR K AVVLQA		28.04%		21906983
14	562	QMSEAH K LLQKLL		58.92%		21906983
15	683	SYDQPK K AEALEA		59.13%		21906983
16	698	ENLNEA K NYFAKV		46.10%		6983
17	726	LYHTLG K TQERNR		50.58%		2190698

The interacting network mediated by proteins: APC5_HUMAN

Metabolic pathway:

Kegg map ID	Pathway
map03008	Ribosome biogenesis in eukaryotes

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