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Protein Name: Anaphase-promoting complex subunit 7

UniprotKB/SwissProt ID: APC7_HUMAN (Q9UJX3)

Gene Name: ANAPC7

Synonyms: APC7

Organism: Homo sapiens (Human).

Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

PDB :
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Graphical Visualization of Ubiquitination Sites:
Overview of Protein Ubiquitination Sites with Functional and Structural Information
InterPro ID Domain
IPR001440
IPR011990
IPR013026
IPR013105


The ubiquitination sites of APC7_HUMAN

No. Position Ubiquitinated Peptide Secondary Structure Solvent Accessibility Substrate Motifs PubMed ID
199YRNAVS K YTMALQ CHHHCC C HHHHHH 37.83%21906983
2153TMLKQD K DAIAIL HHCCHH H HHHHHH 46.71%21906983
3193PSVTSY K EVLRQC HHHHHH H HHCCCC 40.91%21906983
4288FRAGDN K NSVLKF HHCCCH H HHHHHH 56.17%21906983
5293NKNSVL K FEQAQM HHHHHH H HHHHHH 44.70%21906983
6379VQALLL K GAALRN HHHHHH H HHHHHH 46.61%21906983
7467AKTLLD K ALTQRP HHHHHH H HHHCCC 45.31%21906983
8477QRPDYI K AVVKKA CCCCHH H HHHHHH 28.97%21906983
9491LLSREQ K YEDGIA HHHHCC H HHHHHH 45.94%21906983

The interacting network mediated by proteins: APC7_HUMAN

Metabolic pathway:
Kegg map ID Pathway
map03008Ribosome biogenesis in eukaryotes