Protein Name: Apoptosis-resistant E3 ubiquitin protein ligase 1
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UniprotKB/SwissProt ID: AREL1_HUMAN (O15033)
Gene Name: AREL1
Synonyms: KIAA0317
Organism: Homo sapiens (Human).
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits apoptosis by ubiquitinating and targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 and SEPT4/ARTS which are released from the mitochondrion into the cytosol following apoptotic stimulation.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Membrane; Single-pass membrane protein (Potential). Cytoplasm, cytosol.
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Graphical Visualization of Ubiquitination Sites:
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| Overview of Protein Ubiquitination Sites with Functional and Structural Information |  |
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