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Protein Name: E3 ubiquitin-protein ligase ARIH1

UniprotKB/SwissProt ID: ARI1_HUMAN (Q9Y4X5)

Gene Name: ARIH1

Synonyms: ARI, MOP6, UBCH7BP

Organism: Homo sapiens (Human).

Function: E3 ubiquitin-protein ligase, which catalyzes polyubiquitination of target proteins together with ubiquitin- conjugating enzyme E2 UBE2L3. May play a role in protein translation by mediating polyubiquitination of EIF4E2, leading to its subsequent degradation. Acts as the ligase involved in ISGylation of EIF4E2.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Note=Mainly cytoplasmic.

PDB :
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Graphical Visualization of Ubiquitination Sites:
Overview of Protein Ubiquitination Sites with Functional and Structural Information
InterPro ID Domain
IPR001841
IPR002867


The ubiquitination sites of ARI1_HUMAN

No. Position Ubiquitinated Peptide Secondary Structure Solvent Accessibility Substrate Motifs PubMed ID
1142SHFNWD K EKLMER HHCCCC H HHHHHH 48.65%21906983
2156FDGNLE K LFAECH HCCCHH H HHHHCC 52.66%21890473
3253RLITDS K VKLKYQ HHCCCH H HHHHHH 46.31%21906983
4286DCHHVV K VQYPDA CCCEEE E EECCCC 23.64%21890473
5293VQYPDA K PVRCKC EECCCC C CCCCCC 51.96%21906983
6316NWHDPV K CKWLKK HCCCCC C CHHHHH 35.17%21906983
7326LKKWIK K CDDDSE HHHHHH C CCHHHH 33.49%21906983
8398YNEDDA K AARDAQ CCCCCH H HCCCHH 49.96%21906983
9439KLYAQV K QKMEEM HHHHHH H HHHHHC 31.92%21906983
10484FAFYLK K NNQSII EEEEEC C CCCCHH 59.54%21906983
11522DSLQDI K QKVQDK HHHHHH H HHHHHH 52.97%2190698

The interacting network mediated by proteins: ARI1_HUMAN

Metabolic pathway:
Kegg map ID Pathway
map03008Ribosome biogenesis in eukaryotes