UniprotKB/SwissProt ID: ARNT_HUMAN (P27540)
Gene Name: ARNT
Synonyms: BHLHE2
Organism: Homo sapiens (Human).
Function: Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus.
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PDB :
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