logo
   Home | Network Analysis | Data Statistics | Quick Search by Swiss-Prot ID or Keyword

Menu:


Protein Name: BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

UniprotKB/SwissProt ID: BACD1_HUMAN (Q8WZ19)

Gene Name: KCTD13

Synonyms: BACURD1, PDIP1, POLDIP1

Organism: Homo sapiens (Human).

Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus.

Graphical Visualization of Ubiquitination Sites:
Overview of Protein Ubiquitination Sites with Functional and Structural Information

The ubiquitination sites of BACD1_HUMAN

No. Position Ubiquitinated Peptide Secondary Structure Solvent Accessibility Substrate Motifs PubMed ID
134PAAYGL K PLTPNS   33.35%21890473
2168LLASTS K PVVKLL   41.75%21906983
3181HNRSNN K YSYTST   39.56%21906983
4194SDDNLL K NIELFD   60.07%2190698
The interacting network mediated by proteins: BACD1_HUMAN

Metabolic pathway:
Kegg map ID Pathway
map03008Ribosome biogenesis in eukaryotes
 
Version 1.0
© UbiNet's Team: Van-Nui Nguyen, Kai-Yao Huang, Prof. Tzong-Yi Lee, and Prof. K. Robert Lai: Department of Computer Science and Engineering, Yuan Ze University.