Protein Name: BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
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UniprotKB/SwissProt ID: BACD2_HUMAN (Q13829)
Gene Name: TNFAIP1
Synonyms: BACURD2, EDP1
Organism: Homo sapiens (Human).
Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD2) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus. Endosome. Note=Colocalizes with RHOB in endosomes.
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Graphical Visualization of Ubiquitination Sites:
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| Overview of Protein Ubiquitination Sites with Functional and Structural Information |  |
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