UniprotKB/SwissProt ID: BRAP_HUMAN (Q7Z569)
Gene Name: BRAP
Synonyms: RNF52
Organism: Homo sapiens (Human).
Function: Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto- polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm.
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PDB :
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