Protein Name: E3 ubiquitin-protein ligase BRE1B
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UniprotKB/SwissProt ID: BRE1B_HUMAN (O75150)
Gene Name: RNF40
Synonyms: BRE1B, KIAA0661
Organism: Homo sapiens (Human).
Function: Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus.
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Graphical Visualization of Ubiquitination Sites:
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| Overview of Protein Ubiquitination Sites with Functional and Structural Information |  |
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