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Protein Name: Cell division cycle protein 20 homolog

UniprotKB/SwissProt ID: CDC20_HUMAN (Q12834)

Gene Name: CDC20

Organism: Homo sapiens (Human).

Function: Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole.

Graphical Visualization of Ubiquitination Sites:
Overview of Protein Ubiquitination Sites with Functional and Structural Information
InterPro ID Domain
IPR000002
IPR001680
IPR011046
IPR015943

The ubiquitination sites of CDC20_HUMAN

No. Position Ubiquitinated Peptide Secondary Structure Solvent Accessibility Substrate Motifs PubMed ID
162PGRTPG K SSSKVQ CCCCCC C CCCCCC 48.66%21906983
266PGKSSS K VQTTPS CCCCCC C CCCCCC 40.07%21906983
373VQTTPS K PGGDRY CCCCCC C CCCCCC 49.22%21906983
497ASFLLS K ENQPEN CCCCCH H HCCCCC 61.73%21906983
5109NSQTPT K KEHQKA CCCCCC H HHCCCC 58.32%21906983
6114TKKEHQ K AWALNL CHHHCC C CCCCCC 48.04%21906983
7129FDVEEA K ILRLSG HHHHHH H HHCCCC 45.62%21906983
8136ILRLSG K PQNAPE HHCCCC C CCCCCC 39.80%21906983
9155KVLYSQ K ATPGSS CEECCC C CCCCCC 48.57%21906983
10259WDVQQQ K RLRNMT EECCCC C EEEEEE 49.41%21906983
11435KYPTMA K VAELKG ECCCCC E EEEEEC 31.02%21906983
12440AKVAEL K GHTSRV CEEEEE E CCCCCE 39.90%21906983
13485RRRERE K ASAAKS EEEECC C CCCCEE 54.59%21926987
14485RRRERE K ASAAKS EEEECC C CCCCEE 54.59%21926987
15490EKASAA K SSLIHQ CCCCCC E EEECCC 40.05%21926987
16490EKASAA K SSLIHQ CCCCCC E EEECCC 40.05%21926987
The interacting network mediated by proteins: CDC20_HUMAN

Metabolic pathway:
Kegg map ID Pathway
map03008Ribosome biogenesis in eukaryotes
 
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© UbiNet's Team: Van-Nui Nguyen, Kai-Yao Huang, Prof. Tzong-Yi Lee, and Prof. K. Robert Lai: Department of Computer Science and Engineering, Yuan Ze University.