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Protein Name: Cell division cycle protein 23 homolog

UniprotKB/SwissProt ID: CDC23_HUMAN (Q9UJX2)

Gene Name: CDC23

Synonyms: ANAPC8

Organism: Homo sapiens (Human).

Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

Graphical Visualization of Ubiquitination Sites:
Overview of Protein Ubiquitination Sites with Functional and Structural Information
InterPro ID Domain
IPR001440
IPR007192
IPR011990
IPR013026


The ubiquitination sites of CDC23_HUMAN

No. Position Ubiquitinated Peptide Secondary Structure Solvent Accessibility Substrate Motifs PubMed ID
197KAYFDV K EYDRAA HHHHHH H HHHHHC 53.02%21906983
2143SLGPLE K GQVKNE HCCCHH H HHHHHH 63.43%21906983
3147LEKGQV K NEALRE HHHHHH H HHHHHH 40.98%21906983
4281NIRDID K ALSIFN HHHHHH H HHHHHC 52.11%21906983
5453NQLVEA K KCYWRA HHHHHH H HHHCCC 29.85%21906983
6467AVGDVE K MALVKL HHHHHH H HHHHHH 29.35%21906983
7547DTREEG K ALLRQI HHHHHH H HHHHCC 38.86%2190698

The interacting network mediated by proteins: CDC23_HUMAN

Metabolic pathway:
Kegg map ID Pathway
map03008Ribosome biogenesis in eukaryotes