UniprotKB/SwissProt ID: CIP1_HUMAN (Q9NPC3)
Gene Name: CCNB1IP1
Synonyms: C14orf18, HEI10
Organism: Homo sapiens (Human).
Function: Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL- gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over (By similarity). Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis. E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Chromosome. Note=Associates to the synaptonemal complex.
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