Protein Name: Cytokine-inducible SH2-containing protein
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UniprotKB/SwissProt ID: CISH_HUMAN (Q9NSE2)
Gene Name: CISH
Synonyms: G18
Organism: Homo sapiens (Human).
Function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate- recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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Graphical Visualization of Ubiquitination Sites:
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| Overview of Protein Ubiquitination Sites with Functional and Structural Information |  |
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