UbiNet

Protein Name: Protein cereblon

UniprotKB/SwissProt ID: CRBN_HUMAN (Q96SW2)

Gene Name: CRBN

Organism: Homo sapiens (Human).

Function: Component of some DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8. In the complex, may act as a substrate receptor. Regulates the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus. Membrane; Peripheral membrane protein (By similarity).

Graphical Visualization of Ubiquitination Sites:

Overview of Protein Ubiquitination Sites with Functional and Structural Information

InterPro ID	Domain
IPR003111

The ubiquitination sites of CRBN_HUMAN

No.	Position	Ubiquitinated Peptide	Secondary Structure	Solvent Accessibility	Substrate Motifs	PubMed ID
1	43	DSKEAK K PNIINF	HHHHHC C CCEEEE	50.79%		21890473
2	166	IGRQRF K VLELRT	CCHHHH H HHEEHH	48.36%		21890473
3	300	LRIQLL K IGSAIQ	HHHHHH H HHHHHH	54.32%		2189047

The interacting network mediated by proteins: CRBN_HUMAN

Disease:

Disease database	Database Entry	Disease information
KEGG	H00768	Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
OMIM	607417	MENTAL RETARDATION, AUTOSOMAL RECESSIVE 2; MRT2 ;;MENTAL RETARDATION, AUTOSOMAL RECESSIVE 2A
OMIM	609262	CEREBLON; CRBN
HPRD	16750	Mental retardation, nonsyndromic, autosomal recessive, 2A

Metabolic pathway:

Kegg map ID	Pathway
map03008	Ribosome biogenesis in eukaryotes

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