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Protein Name: Cullin-9

UniprotKB/SwissProt ID: CUL9_HUMAN (Q8IWT3)

Gene Name: CUL9

Synonyms: H7AP1, KIAA0708, PARC

Organism: Homo sapiens (Human).

Function: Cytoplasmic anchor protein in p53-associated protein complex. Regulates the subcellular localization of p53 and subsequent function. Seems to be part of an atypical cullin-RING- based E3 ubiquitin-protein ligase complex. In vitro, complexes of CUL9/PARC with either CUL7 or TP53 contain E3 ubiquitin-protein ligase activity.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm.

PDB :
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Graphical Visualization of Ubiquitination Sites:
Overview of Protein Ubiquitination Sites with Functional and Structural Information


The ubiquitination sites of CUL9_HUMAN

No. Position Ubiquitinated Peptide Secondary Structure Solvent Accessibility Substrate Motifs PubMed ID
187GERALS K GLQHEP   65.57%21890473
2571NSQIYT K YGLLSN   21.98%21906983
31657QLQRLD K LFLEQE   45.81%21906983
41881LLVRIL K AHGEKG   35.65%21890473
52144VISKYE K ALLRGY   41.04%2189047

The interacting network mediated by proteins: CUL9_HUMAN

Metabolic pathway:
Kegg map ID Pathway
map03008Ribosome biogenesis in eukaryotes