UbiNet

Protein Name: DDB1- and CUL4-associated factor 17

UniprotKB/SwissProt ID: DCA17_HUMAN (Q5H9S7)

Gene Name: DCAF17

Synonyms: C2orf37

Organism: Homo sapiens (Human).

Function: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Membrane; Multi-pass membrane protein (Potential). Nucleus, nucleolus. Note=According to PubMed:19026396, it is a nucleolar protein, while sequence analysis programs clearly predict 2 transmembrane regions.

Graphical Visualization of Ubiquitination Sites:

Overview of Protein Ubiquitination Sites with Functional and Structural Information

The ubiquitination sites of DCA17_HUMAN

No.	Position	Ubiquitinated Peptide	Secondary Structure	Solvent Accessibility	Substrate Motifs	PubMed ID
1	167	QEVIAV K SAQNRG		30.93%		2190698

The interacting network mediated by proteins: DCA17_HUMAN

Disease:

Disease database	Database Entry	Disease information
KEGG	H00682	Woodhouse-Sakati syndrome; Hypogonadism, alopecia, diabetes mellitus, mental retardation, and extrap
OMIM	241080	HYPOGONADISM, ALOPECIA, DIABETES MELLITUS, MENTAL RETARDATION, AND EXTRAPYRAMIDAL SYNDROME ;
OMIM	612515	CHROMOSOME 2 OPEN READING FRAME 37; C2ORF37

Metabolic pathway:

Kegg map ID	Pathway
map03008	Ribosome biogenesis in eukaryotes

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