UniprotKB/SwissProt ID: DCNL1_HUMAN (Q96GG9)
Gene Name: DCUN1D1
Synonyms: DCUN1L1, RP42, SCCRO
Organism: Homo sapiens (Human).
Function: Part of an E3 ubiquitin ligase complex for neddylation. Required for neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes by enhancing the rate of cullins neddylation. Functions to recruit the NEDD8-charged E2 enzyme to the cullin component. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity).
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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PDB :
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