UniprotKB/SwissProt ID: DTX2_HUMAN (Q86UW9)
Gene Name: DTX2
Synonyms: KIAA1528, RNF58
Organism: Homo sapiens (Human).
Function: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Partially nuclear.
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