UniprotKB/SwissProt ID: DTX4_HUMAN (Q9Y2E6)
Gene Name: DTX4
Synonyms: KIAA0937, RNF155
Organism: Homo sapiens (Human).
Function: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations (By similarity). Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm (By similarity).
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