UbiNet

Protein Name: E3 ubiquitin-protein ligase DZIP3

UniprotKB/SwissProt ID: DZIP3_HUMAN (Q86Y13)

Gene Name: DZIP3

Synonyms: KIAA0675

Organism: Homo sapiens (Human).

Function: E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Able to specifically bind RNA.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm.

Graphical Visualization of Ubiquitination Sites:

Overview of Protein Ubiquitination Sites with Functional and Structural Information

InterPro ID	Domain
IPR001841
IPR013083

The ubiquitination sites of DZIP3_HUMAN

No.	Position	Ubiquitinated Peptide	Secondary Structure	Solvent Accessibility	Substrate Motifs	PubMed ID
1	212	LQEIGD K NDHWFD	HHHHHC C CCCCCC	60.09%		21906983
2	372	DTDIRP K ISLKFN	CCCCCE E EEECCC	34.77%		21906983
3	380	SLKFNT K DEMPIF	EECCCC C CCCCEE	53.44%		21906983
4	703	SVSRLI K DDASDV	HHHHHH H CCHHHH	54.90%		21906983
5	738	EQGSAG K VTTDYG	HCCCCC C CCCCHH	35.80%		21906983
6	748	DYGETE K ERLARQ	CHHHHH H HHHHHH	56.40%		21906983
7	786	ENQMQI K KKDKII	CCHHHH H HHHHHH	36.56%		21906983
8	824	NEIKNL K EQLSMK	CCCHHH H HHHHHH	53.46%		21906983
9	846	NLESTM K TYVSKL	HHHHHH H HHHHHH	36.47%		21890473
10	851	MKTYVS K LNAETS	HHHHHH H HHHHHH	35.40%		21906983
11	936	YNEQIN K VKQGFA	HHHHHH H HHCCHH	53.06%		21906983
12	1042	RITDRL K TAFPQQ	CCCCCC C CCCCCC	38.41%		21890473
13	1051	FPQQTR K ELTDFL	CCCCCC H HHHHHH	61.54%		21890473
14	1087	SQFIDP K KSQSQG	HHHHHH H HHCCCC	62.40%		2190698

The interacting network mediated by proteins: DZIP3_HUMAN

Metabolic pathway:

Kegg map ID	Pathway
map03008	Ribosome biogenesis in eukaryotes

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