UniprotKB/SwissProt ID: ERCC8_HUMAN (Q13216)
Gene Name: ERCC8
Synonyms: CKN1, CSA
Organism: Homo sapiens (Human).
Function: Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription- coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus (Probable).
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