UniprotKB/SwissProt ID: FBSP1_HUMAN (P0C2W1)
Gene Name: FBXO45
Synonyms: FBX45
Organism: Homo sapiens (Human).
Function: Component of E3 ubiquitin ligase complexes. Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration (By similarity). Plays a role in the regulation of neurotransmission at mature neurons (By similarity). May controls synaptic activity by controlling UNC13A via ubiquitin dependent pathway (By similarity). Specifically recognizes TP73, promoting its ubiquitination and degradation.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell junction, synapse, postsynaptic cell membrane (By similarity). Cell junction, synapse, presynaptic cell membrane (By similarity).
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