UniprotKB/SwissProt ID: FBX11_HUMAN (Q86XK2)
Gene Name: FBXO11
Synonyms: FBX11, PRMT9, VIT1
Organism: Homo sapiens (Human).
Function: Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2 and BCL6. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Chromosome.
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