logo
   Home | Network Analysis | Data Statistics | Quick Search by Swiss-Prot ID or Keyword

Menu:


Protein Name: F-box only protein 22

UniprotKB/SwissProt ID: FBX22_HUMAN (Q8NEZ5)

Gene Name: FBXO22

Synonyms: FBX22

Organism: Homo sapiens (Human).

Function: Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, myofibril, sarcomere, Z line (By similarity).

Graphical Visualization of Ubiquitination Sites:
Overview of Protein Ubiquitination Sites with Functional and Structural Information
InterPro ID Domain
IPR001810

The ubiquitination sites of FBX22_HUMAN

No. Position Ubiquitinated Peptide Secondary Structure Solvent Accessibility Substrate Motifs PubMed ID
140LTFLPA K ALLRVA HHHCCH H HHHHHH 37.31%21890473
2300EDVSDE K TAEAAM CCCCHH H HHHHHH 59.01%2190698
The interacting network mediated by proteins: FBX22_HUMAN

Metabolic pathway:
Kegg map ID Pathway
map03008Ribosome biogenesis in eukaryotes
 
Version 1.0
© UbiNet's Team: Van-Nui Nguyen, Kai-Yao Huang, Prof. Tzong-Yi Lee, and Prof. K. Robert Lai: Department of Computer Science and Engineering, Yuan Ze University.