UniprotKB/SwissProt ID: FBX31_HUMAN (Q5XUX0)
Gene Name: FBXO31
Synonyms: FBX14, FBX31
Organism: Homo sapiens (Human).
Function: Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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