UniprotKB/SwissProt ID: FBX3_HUMAN (Q9UK99)
Gene Name: FBXO3
Synonyms: FBX3
Organism: Homo sapiens (Human).
Function: Substrate recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53- dependent transactivation.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Note=Colocalizes with PML at the peripheries of nuclear bodies.
| |
|
