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Protein Name: F-box only protein 42

UniprotKB/SwissProt ID: FBX42_HUMAN (Q6P3S6)

Gene Name: FBXO42

Synonyms: FBX42, JFK, KIAA1332

Organism: Homo sapiens (Human).

Function: Substrate-recognition component of some SCF (SKP1-CUL1- F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

Graphical Visualization of Ubiquitination Sites:
Overview of Protein Ubiquitination Sites with Functional and Structural Information
InterPro ID Domain
IPR001810
IPR006652
IPR011043
IPR011498
IPR015915

The ubiquitination sites of FBX42_HUMAN

No. Position Ubiquitinated Peptide Secondary Structure Solvent Accessibility Substrate Motifs PubMed ID
1159RLDLNS K EWIRPL EEECCC C CEEECC 56.87%21906983
2493GSLPDQ K DLRLGS CCCCCC C CEEEEE 67.14%21906983
3507DLNWDL K PASSSN CCCCCC C CCCCCC 35.74%21906983
4564RSLEAI K AMSSKG HHHHHH H HHHCCC 45.12%20972266
The interacting network mediated by proteins: FBX42_HUMAN

Metabolic pathway:
Kegg map ID Pathway
map03008Ribosome biogenesis in eukaryotes
 
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© UbiNet's Team: Van-Nui Nguyen, Kai-Yao Huang, Prof. Tzong-Yi Lee, and Prof. K. Robert Lai: Department of Computer Science and Engineering, Yuan Ze University.