Protein Name: F-box/LRR-repeat protein 3
|
UniprotKB/SwissProt ID: FBXL3_HUMAN (Q9UKT7)
Gene Name: FBXL3
Synonyms: FBL3A, FBXL3A
Organism: Homo sapiens (Human).
Function: Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2. Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex. FBXL3 probably recognizes and binds phosphorylated CRY1 and CRY2.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm. Note=Predominantly nuclear.
| |
|
Graphical Visualization of Ubiquitination Sites:
|
| Overview of Protein Ubiquitination Sites with Functional and Structural Information |  |
|
