UniprotKB/SwissProt ID: FBXL5_HUMAN (Q9UKA1)
Gene Name: FBXL5
Synonyms: FBL4, FBL5, FLR1
Organism: Homo sapiens (Human).
Function: Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, perinuclear region.
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