UniprotKB/SwissProt ID: FBXW7_HUMAN (Q969H0)
Gene Name: FBXW7
Synonyms: FBW7, FBX30, SEL10
Organism: Homo sapiens (Human).
Function: Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Isoform 1: Nucleus, nucleoplasm. Isoform 2: Cytoplasm. Isoform 4: Nucleus, nucleolus. Nucleus (By similarity).
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