UniprotKB/SwissProt ID: FBXW8_HUMAN (Q8N3Y1)
Gene Name: FBXW8
Synonyms: FBW6, FBW8, FBX29, FBXO29, FBXW6
Organism: Homo sapiens (Human).
Function: Substrate-recognition component of a SCF-like E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. In complex with CUL7, mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, perinuclear region. Golgi apparatus. Note=Colocalizes with CUL7 at the Golgi apparatus in neurons (By similarity).
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