UniprotKB/SwissProt ID: FEM1B_HUMAN (Q9UK73)
Gene Name: FEM1B
Synonyms: F1AA, KIAA0396
Organism: Homo sapiens (Human).
Function: Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus. Note=In the nucleus, the protein level increased slightly after camptothecin (CPT) treatment. Associated with chromatin.
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